IL-33/ST2 signaling boosts inflammation and pain
نویسندگان
چکیده
منابع مشابه
IL-33/ST2 signaling boosts inflammation and pain.
We read with interest the work of Taracanova et al. (1) on the synergic effect of substance P (SP) and IL33 over TNF-α production. Notably, IL-33 potentiates SP-induced TNF-α production by more than 100-fold in mast cells. Both IL-33 and SP increase the expression of each other receptor, and more interestingly, ST2 coimmunoprecipitates with neurokinin-1 (NK-1, SP receptor), demonstrating a form...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1716120114